CHEMOGENOMIC ANALYSIS OF G-PROTEIN COUPLED RECEPTORS AND THEIR LIGANDS DECIPHERS LOCKS AND KEYS GOVERNING DIVERSE ASPECTS OF SIGNALLING.

Chemogenomic analysis of G-protein coupled receptors and their ligands deciphers locks and keys governing diverse aspects of signalling.

Understanding the molecular mechanism of signalling in the important super-family of G-protein-coupled receptors (GPCRs) is causally related to questions of how and where these receptors can be activated us polo assn mens sweaters or inhibited.In this context, it is of great interest to unravel the common molecular features of GPCRs as well as thos

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Complete and sustained resolution of calcinosis universalis in a juvenile dermatomyositis case with mycophenolate mofetil

Juvenile dermatomyositis (JDM) is a rare, multisystemic, idiopathic vasculopathy mainly affecting the muscles and the skin.Gastrointestinal system, lungs, joints and heart may also be involved.Characteristic skin findings are heliotrope rash and Gottron papules but extensive skin involvement as large necrotic lesions are rarely reported.Calcinosis

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Study of glycerol diffusion in skin and myocardium ex vivo under the conditions of developing alloxan-induced diabetes

Diabetes mellitus is one of widespread diseases, the development of which impairs the here functioning of organism vital organs.The study of the processes that occur in tissues under diabetic conditions facilitates the development of diabetes diagnostics and treatment methods, as well as the prognosis of its complications.The paper reports a compar

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